Within the realm of genetic regulation, chromatin modifications such as histone methylation and acetylation play pivotal roles in the transcriptional control of genes. Disruptions in these processes ...

The human genome is about two meters long, yet it fits inside a nucleus only ~10 micrometers in diameter. A research team led ...

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can also lead to cancer and other diseases. To better understand how chromatin ...

DNA inside the nucleus is not packed as a rigid regular fiber—linker histone H1 dynamically binds and loosely "glues" ...

Every cell in your body faces the same engineering puzzle: how to cram roughly two meters of DNA into a nucleus just a few ...

Every cell in a body contains the same genetic sequence, yet each cell expresses only a subset of those genes. These cell-specific gene expression patterns, which ensure that a brain cell is different ...

Chromatin's structure plays an important regulatory role in DNA template-dependent processes including transcription, replication, recombination, repair, segregation, chromosomal stability, cell cycle ...

CTCF is widely recognized for its essential role in mediating chromatin loops to regulate gene expression, particularly by modulating enhancer-promoter (EP) interactions. However, acute depletion of ...

Immune cells in the blood may be intimately involved with Alzheimer’s pathogenesis in the brain. At least, according to their chromatin. A study published January 31 in Neuron reported that in people ...