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This work was financially supported by the National Natural Science Foundation of China (32172402), Zhejiang Provincial Natural Science Foundation of China (LZ26C140005), and the Hangzhou Normal ...

Acute myocardial infarction (MI) remains one of the major causes of death worldwide, and innovative treatment strategies for MI represent a major challenge in cardiovascular medicine. Caloric ...

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.joc.4c02515. Experimental Procedure, characterization data, X-ray ...

The growing burden of metabolic disorders manifested by hypertension, type 2 diabetes mellitus, hyperlipidemia, obesity and non-alcoholic fatty liver disease presents a significant global health ...

This fundamental work demonstrates that ABHD6 regulates AMPAR gating kinetics in a TARP γ-2-dependent manner. The evidence in this study is compelling. This study will be of interest to readers in the ...

This study provides important biophysical insights into the molecular mechanism underlying the association of alpha-synuclein chains, which is essential for understanding the pathogenesis of Parkinson ...

Efficacy, safety, and biomarkers of neoadjuvant niraparib monotherapy in homologous recombination deficiency (HRD) advanced ovarian cancer: A prospective, multicenter, phase II, single-arm NANT study.

First-in-human, phase 1/2 study of GSK4524101, an oral DNApolymerase theta inhibitor (POLQi), alone or combined with the poly(ADP-ribose) polymerase (PARP) inhibitor (PARPi) niraparib in adults with ...

The strongest force in the universe is called, aptly, the strong force. We never get to witness its fearsome power because it works only across subatomic distances, where it binds quarks together ...