This work was financially supported by the National Natural Science Foundation of China (32172402), Zhejiang Provincial Natural Science Foundation of China (LZ26C140005), and the Hangzhou Normal ...

Acute myocardial infarction (MI) remains one of the major causes of death worldwide, and innovative treatment strategies for MI represent a major challenge in cardiovascular medicine. Caloric ...

Good for the heart, beta glucan (β-glucans) foods and supplements help everything from brain function to cancer prevention. Beta glucan is found in plants such as oats and barley. It comes from the ...

β-adrenergic receptor (β-AR) overactivation is a major pathological cue associated with cardiac injury and diseases. AMPK (AMP-activated protein kinase), a conserved energy sensor, regulates energy ...

First-in-human, phase 1/2 study of GSK4524101, an oral DNApolymerase theta inhibitor (POLQi), alone or combined with the poly(ADP-ribose) polymerase (PARP) inhibitor (PARPi) niraparib in adults with ...

Whether you inherit alpha- or beta-thalassemia depends on which genes are affected. The number of affected genes can determine the subtype of alpha- or beta-thalassemia and the severity of your ...

Casomorphins are peptides formed by the enzymatic breakdown of the milk protein casein during digestion. The peptides typically contain from three to eight amino acids. Casein in milk produced by ...

Sickle cell beta-thalassemia refers to an inherited condition that impacts hemoglobin. People with the condition have different changes in each copy of their hemoglobin gene. One causes red blood ...

The transforming growth factor-β (TGF-β) signaling plays a critical role in the development and tissue homeostasis in metazoans, and deregulation of TGF-β signaling leads to many pathological ...

The transforming growth factor β (TGF-β) pathway, which is well studied for its ability to inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial-mesenchymal transition ...

fDepartment of Medicine, Department of Pharmacology, Department of Molecular Biology and Microbiology, Department of Biochemistry, and Case Center for Proteomics and Bioinformatics, Case Western ...